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Critical Role of TLR4 on the microglia activation induced by maternal LPS exposure leading to ASD-like behavior of offspring

Post-treatment, we recommend avoiding sun exposure and applying soothing creams

To conclude, the endocannabinoid system in the human body plays a key role in a multitude of physiological functions including inflammatory and immunological responses, pain, temperature control, endocrine regulation, feeding behaviour, learning and memory, emotional processing, and sleep

It is therefore assumed that transcription from gdhA P2 serves to enhance gdhA expression when the concentration of -ketoglutarate is low, as during invasive disease, both to enhance the activity of the TCA cycle in the catabolic reaction, and to provide L-glutamate for glutathione biosynthesis in the anabolic reaction

Adapted from (O'Neill et al., 2016

Conclusions The inflammatory process seen in MS is due to an excess production of proinflammatory cytokines, which leads to increased secretion of ROS